Dermal delivery of amitriptyline for topical analgesia
نویسندگان
چکیده
منابع مشابه
Formulation effects of topical emulsions on transdermal and dermal delivery.
It has been recognized that the vehicle in which a permeant is applied to the skin has a distinctive effect on the dermal and transdermal delivery of active ingredients. The cutaneous and percutaneous absorptions can be enhanced, e.g. by an increase in thermodynamic activity, supersaturation and penetration modifiers. Furthermore, dermal and transdermal delivery can be influenced by the interac...
متن کاملTopical amitriptyline in healthy volunteers.
BACKGROUND AND OBJECTIVES The antidepressant amitriptyline is used as an adjuvant in the treatment of a variety of chronic pain conditions. This drug interacts with many receptors and ion channels, such as Na+ channels. In a randomized, double-blinded, and placebo-controlled trial, we investigated whether amitriptyline also is capable of providing cutaneous analgesia when applied topically in 1...
متن کاملAmitriptyline for prolonged cutaneous analgesia in the rat.
BACKGROUND Amitriptyline has been reported to be a more potent local anesthetic than bupivacaine. In keeping with the objective of identifying drugs for prolonged cutaneous analgesia, the authors compared the cutaneous analgesic effectiveness of amitriptyline and bupivacaine in rats. METHODS Rats were subcutaneously injected on shaved dorsal skin. The skin wheal raised after injection of 0.6 ...
متن کاملTopical analgesia for acute otitis media.
BACKGROUND Acute otitis media (AOM) is a spontaneously remitting disease for which pain is the most distressing symptom. Antibiotics are now known to have less benefit than previously assumed. OBJECTIVES To assess the effectiveness of topical analgesia for AOM. SEARCH STRATEGY We searched the Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library Issue 2, 2006), MEDL...
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ژورنال
عنوان ژورنال: Drug Delivery and Translational Research
سال: 2021
ISSN: 2190-393X,2190-3948
DOI: 10.1007/s13346-021-00982-x